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The methodology’s non-invasiveness is crucial not only for identifying early resistance to treatment or predicting relapse but also for identifying cancer risk through molecular analyses in populations predisposed to certain cancers (such as colorectal cancer in individuals with polyposis, hepatocellular carcinoma in those with cirrhosis, lung cancer in COPD patients with lung nodules, or ovarian cancer in individuals with ovarian polyps, among others).
Inicio - Área Aplicada: Medicina Personalizada - Detección, Diagnóstico, Seguimiento y Pronóstico de Enfermedades - Liquid Biopsy and Cancer Interception | PI: Dr. Maria José Serrano
In the era of Precision Medicine, liquid biopsy has emerged as a pivotal clinical tool due to its non-invasive nature, allowing real-time monitoring of the tumoral process in each patient. The methodology’s non-invasiveness is crucial not only for identifying early resistance to treatment or predicting relapse but also for identifying cancer risk through molecular analyses in populations predisposed to certain cancers (such as colorectal cancer in individuals with polyposis, hepatocellular carcinoma in those with cirrhosis, lung cancer in COPD patients with lung nodules, or ovarian cancer in individuals with ovarian polyps, among others). 79 STRATEGIC PLAN 2024-2027 Beyond its clinical applications, liquid biopsy enables deeper insights into cancer biology. Analysis of liquid biopsy components provides valuable biological information about the initiation of carcinogenesis and the progression of cancer through various stages of tumoral dissemination. This knowledge enhances our understanding of the underlying mechanisms driving cancer development and progression, facilitating the development of more effective diagnostic and therapeutic strategies tailored to individual patients.
To achieve this goal, the following sub-lines are our focus of interest:
Molecular analyses of circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) in the early stages of cancer and chronic inflammatory diseases signify a groundbreaking approach in precision medicine. By employing fragmentomic and epigenomic methodologies, we delve into the intricate molecular signatures present in these circulating nucleic acids, providing valuable insights into disease onset, progression, and treatment response.
In cancer, the presence of ctDNA and cfDNA in circulation offers a glimpse into the genomic landscape of tumors. However, the reliance on mutation-based detection assays for ctDNA raises concerns, particularly regarding their utility in identifying mutations, copy number alterations, and chromosomal rearrangements associated with early-stage malignancies. Fragmentomic techniques, encompassing not just fragment size but also other properties of cfDNA, enable the characterization of DNA fragments shed by tumors, aiding in the identification of specific genetic aberrations linked to early-stage cancers.
This molecular information holds immense potential for facilitating the early detection of cancer, allowing for timely intervention and improved treatment outcomes. Additionally, epigenomic analyses of ctDNA and cfDNA unveil dynamic changes in DNA methylation patterns, histone modifications, and chromatin structure, which play crucial roles in regulating gene expression. These epigenetic alterations serve as sensitive biomarkers for cancer and chronic inflammatory diseases, reflecting underlying pathogenic processes and disease progression.
By integrating epigenomic approaches with fragmentomic analyses, we enhance the sensitivity and specificity of liquid biopsy-based diagnostics, enabling clinicians to distinguish between malignant and benign conditions with greater accuracy. Furthermore, the fragmentation pattern of cfDNA mirrors epigenetic regulation, with breakpoint coordinates clustering at specific locations in the genome. These clusters, termed preferred end coordinates, provide insights into chromatin accessibility and tissue-specific nucleosome positioning, transcription factor binding sites, and gene expression.
Overall, molecular analyses of ctDNA and cfDNA in the early stages of cancer and chronic inflammatory diseases represent a paradigm shift in disease diagnosis and 80 STRATEGIC PLAN 2024-2027 management, offering promising avenues for personalized medicine and improved patient outcomes.
The interaction between the immune system and tumor cells is a complex and dynamic process that plays a critical role in cancer development, progression, and response to therapy. The immune system serves as a crucial defense mechanism against cancer by recognizing and eliminating abnormal cells. However, tumor cells have evolved various strategies to evade immune surveillance and manipulate the immune microenvironment to their advantage. Our research is focused on understanding the survival mechanisms of circulating tumor cells (CTCs) in the bloodstream, where they face attacks from the immune system. Despite this hostile environment, CTCs engage in active interactions with various immune cell types , including platelets, myeloid cells, macrophages, and neutrophils. These interactions contribute to CTC survival and acquisition of a metastatic phenotype, promoting metastasis formation. The acquisition of these characteristics involves the exchange of biomolecules from immune cells to circulating tumor cells (CTCs).
The term «extracellular vesicles» (EVs) refers to a diverse group of membranous structures released by cells into their extracellular environment. These vesicles play crucial roles in intercellular communication by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells.
One key role of EVs in cancer is their ability to facilitate tumor cell communication with the surrounding microenvironment. Cancer cells release EVs containing signaling molecules that can influence neighbouring cells, such as stromal cells, endothelial cells, and immune cells, promoting tumor growth, angiogenesis, and immune evasion. Additionally, EVs derived from tumor-associated stromal cells can contribute to the establishment of a tumor-supportive microenvironment by modulating the behavior of cancer cells and other stromal components.
Moreover, EVs play a crucial role in mediating communication between primary tumor cells and distant metastatic sites. Tumor-derived EVs can travel through the bloodstream or lymphatic system, carrying bioactive molecules that prepare premetastatic niches and facilitate the seeding and colonization of metastatic cells at distant sites. These EV-mediated interactions contribute to the formation of secondary tumors and the spread of cancer throughout the body.
In our lab, we aim to identify the diverse cargo carried by these EVs, with a particular focus on their proteomic and miRNA components, and their relationship with the induction of metastasis and resistance to treatment.
The social impact of this line of research is profound and multifaceted. Firstly, in the era of Precision Medicine, advancements in liquid biopsy techniques offer noninvasive methods for early cancer detection and monitoring, providing individuals with more accessible and timely diagnosis. This can lead to improved treatment outcomes and increased survival rates. Moreover, the ability to identify cancer risk through molecular analyses in predisposed populations holds the potential to revolutionize preventive healthcare strategies, empowering individuals to take proactive steps in managing their health. Recently, our hospitals implemented ctDNA analyses according to our protocol in clinical practice for metastatic lung cancer. In this way, we are developing the first Clinical trial of Liquid Biopsy using NovaSeq in Andalucia; this project involves all provinces of this region. Additionally, regarding our analyses based on CTCs, we have developed three different patents in the GENyO center. Similarly, and more recently, we have developed a patent for the therapeutic use of EVs.
Our group is continuously pursuing new projects both on a national and international scale. Establishing international networks is essential for us, and we have strong collaborations with France, Italy, and the USA. Our objectives include not only translational research but also clinical trials, given our strong collaboration with hospitals and clinicians. Additionally, our lab is a reference for liquid biopsy, and we host students from different countries, enhancing our international visibility.
EXPEDIENTE: PIP-0237-2024. Consejeria de Salud 390.000e
Entidad de Fecha de inicio‐fin: 01/03/2022 01/03/2025 Cuantía total: 60.000 €
Fundación Mutua Madrileña Fecha de inicio‐fin: 2023 ‐ 2025 Cuantía: 55000
Fecha 2024‐2026 Entidad financiadora TEMPUS. Cuantía: 495.000
Start-End date: 01/01/2024 – 31/12/2025 Duration: 2 years Total amount: 144.100 €
IP: Gabriel Ortega
Start-End date: 01/01/2023 – 31/12/2025
Duration: 3 years Total amount: 86.515 €
IP: Gabriel Ortega
Autores: Garcia-Diaz A, Moyano-Rodríguez MJ, Garrido-Navas MDC, de Miguel-Perez D, Expósito-Hernández J, Alcázar-Navarrete B, Ortuño F, Landeira D, Romero PJ, Garcia-Moreno A, Lorente JA, Lopez-Hidalgo J, Bayarri-Lara C, Serrano MJ
10/2024 - Archivos de bronconeumologia
Autores: Reduzzi C, Nicolo' E, Singhal S, Venetis K, Ortega-Franco A, de Miguel-Perez D, Dipasquale A, Gouda MA, Saldanha EF, Kasi PM, Jantus-Lewintre E, Fusco N, Malapelle U, Gandara DR, Rolfo C, Serrano MJ, Cristofanilli M, International Society of Liquid Biopsy (ISLB)
11/2024 - Critical reviews in oncology/hematology
Autores: González A, Díaz C, Mena C, Valenzuela C, Cooper A, Inostroza P, Coloma B, Serrano MJ, Gil F
08/2023 - Revista medica de Chile
Autores: Cappellano A, Gorostegui M, Gonzalez-Ramella O, Filho NPC, Valencia D, Chantada L, Sampor C, Serrano MJ, Macedo C, Ramirez O, Sardinas S, Lezcano E, Calderón P, Gamboa Y, Fu L, Gómez W, Schelotto M, Ugaz C, Lobos P, Aguiar SDS, Moreno K, Palma J, Sánchez G, Moschella F, Gassant PYH, Velasquez T, Quintero K, Moreno F, Villarroel M, Fuentes Alabi S, Vasquez L, Challinor J, Chantada GL
06/2024 - Pediatric blood & cancer
Autores: Serrano MJ, Goudet J, Cumer T
01/2024 - PloS one
Autores: Frullanti E, Serrano MJ
12/2023 - Frontiers in genetics
Autores: Bernués-Caudillo L, Albornos-Muñoz L, Rodrigo MPF, García MÁ, Benito MR, Serrano MJR, Navarro PG, Pérez PL, Sotelo SG, Moreno-Casbas MT, Vrbová T, Klugar M, Klugarová J, Gonzalez-María E
12/2023 - JBI evidence implementation
Autores: de Miguel-Perez D, Ortega FG, Tejada RG, Martínez-Única A, Peterson CB, Russo A, Gunasekaran M, Cardona AF, Amezcua V, Lorente JA, Expósito Hernández J, Rolfo C, Serrano MJ
11/2023 - Biomarker research
Autores: Aguilera M, Tobar-Calfucoy E, Rojas-Martínez V, Norambuena R, Serrano MJ, Cifuentes O, Zamudio MS, San Martín D, Lara P, Sabag A, Zabner M, Tichy D, Camejo P, León L, Pino M, Ulloa S, Rojas F, Pieringer C, Muster C, Castillo D, Ferreira N, Avendaño C, Canaval M, Pieringer H, Cifuentes P, Cifuentes Muñoz N
12/2023 - Poultry science
Autores: Serrano MJ, Rolfo C, Expósito-Hernandez J, Garrido-Navas C, Lopez-Hidalgo J, Denninghoff V
01/2023 - International review of cell and molecular biology
Autores: González-Martínez C, Garrido-Navas C, Alcaide-Lucena M, Antonio Lorente J, Lopez-Hidalgo J, Ortega FG, Serrano MJ
08/2023 - Critical reviews in oncology/hematology
Autores: Calero-Castro FJ, Pereira S, Laga I, Villanueva P, Suárez-Artacho G, Cepeda-Franco C, de la Cruz-Ojeda P, Navarro-Villarán E, Dios-Barbeito S, Serrano MJ, Fresno C, Padillo-Ruiz J
02/2023 - International journal of molecular sciences
Autores: Far-Riera AM, Perez-Uribarri C, Serrano MJE, González JMR
11/2022 - Journal of hand surgery global online
Autores: Serrano MJ, Malapelle U
01/2023 - Journal for immunotherapy of cancer
Autores: Roa-Colomo A, López Garrido MÁ, Molina-Vallejo P, Rojas A, Sanchez MG, Aranda-García V, Salmeron J, Romero-Gomez M, Muntane J, Padillo J, Alamo JM, Lorente JA, Serrano MJ, Garrido-Navas MC
11/2022 - Frontiers in molecular biosciences
Autores: de Miguel-Perez D, Russo A, Gunasekaran M, Buemi F, Hester L, Fan X, Carter-Cooper BA, Lapidus RG, Peleg A, Arroyo-Hernández M, Cardona AF, Naing A, Hirsch FR, Mack PC, Kaushal S, Serrano MJ, Adamo V, Arrieta O, Rolfo C
02/2023 - Cancer
Autores: Ortega FG, Gómez GE, González-Martinez C, Valero T, Expósito-Hernández J, Puche I, Rodriguez-Martinez A, Serrano MJ, Lorente JA, Fernández-Baldo MA
09/2022 - Cancers
Autores: Ortega FG, Gomez GE, Boni C, García IC, Navas CG, D'vries RF, Molina Vallejos MP, Serrano MJ, Messina GA, Hernández JE, Fernández-Baldo MA
01/2023 - Talanta
Autores: Duschek S, de Guevara CML, Serrano MJF, Montoro CI, López SP, Reyes Del Paso GA
07/2022 - Behavioural neurology
Autores: Barron-Montenegro R, Rivera D, Serrano MJ, García R, Álvarez DM, Benavides J, Arredondo F, Álvarez FP, Bastías R, Ruiz S, Hamilton-West C, Castro-Nallar E, Moreno-Switt AI
05/2022 - Frontiers in cellular and infection microbiology
Autores: de Miguel-Perez D, Russo A, Arrieta O, Ak M, Barron F, Gunasekaran M, Mamindla P, Lara-Mejia L, Peterson CB, Er ME, Peddagangireddy V, Buemi F, Cooper B, Manca P, Lapidus RG, Hsia RC, Cardona AF, Naing A, Kaushal S, Hirsch FR, Mack PC, Serrano MJ, Adamo V, Colen RR, Rolfo C
06/2022 - Journal of experimental & clinical cancer research : CR
Autores: Ruocco MR, Lamberti A, Serrano MJ, Fiume G, Arcucci A
04/2022 - Frontiers in cell and developmental biology
Autores: Molina-Zayas M, Garrido-Navas C, García-Puche JL, Barwell J, Pedrinaci S, Atienza MM, García-Linares S, de Haro-Muñoz T, Lorente JA, Serrano MJ, Poyatos-Andújar A
05/2022 - Molecular genetics and genomics : MGG
Autores: González-Fandos E, Martínez-Laorden A, Abad-Fau A, Sevilla E, Bolea R, Serrano MJ, Mitjana O, Bonastre C, Laborda A, Falceto MV, Pagán R
03/2022 - Animals : an open access journal from MDPI
Autores: Rodriguez-Martinez A, Simon-Saez I, Perales S, Garrido-Navas C, Russo A, de Miguel-Perez D, Puche-Sanz I, Alaminos C, Ceron J, Lorente JA, Molina MP, Gonzalez C, Cristofanilli M, Ortigosa-Palomo A, Real PJ, Rolfo C, Serrano MJ
02/2022 - Theranostics
Autores: Baiges A, Cerda E, Amicone C, Téllez L, Alvarado-Tapias E, Puente A, Fortea JI, Llop E, Rocha F, Orts L, Ros-Fargas O, Vizcarra P, Zekrini K, Lounes OA, Touati G, Jiménez-Esquivel N, Serrano MJ, Falgà A, Magaz M, Olivas P, Betancourt F, Perez-Campuzano V, Turon F, Payancé A, Goria O, Rautou PE, Hernández-Gea V, Villanueva C, Albillos A, Plessier A, García-Pagán JC
07/2022 - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Autores: Ruiz-Rodríguez AJ, Molina-Vallejo MP, Aznar-Peralta I, González Puga C, Cañas García I, González E, Lorente JA, Serrano MJ, Garrido-Navas MC
12/2021 - Cancers
Autores: Padillo-Ruiz J, Suarez G, Pereira S, Calero-Castro FJ, Tinoco J, Marin L, Bernal C, Cepeda-Franco C, Alamo JM, Almoguera F, Macher HC, Villanueva P, García-Fernandez FJ, Gallego I, Romero M, Gomez-Bravo MA, Denninghoff V, Serrano MJ
12/2021 - Cancers
Autores: Malapelle U, Pisapia P, Addeo A, Arrieta O, Bellosillo B, Cardona AF, Cristofanilli M, De Miguel-Perez D, Denninghoff V, Durán I, Jantus-Lewintre E, Nuzzo PV, O'Byrne K, Pauwels P, Pickering EM, Raez LE, Russo A, Serrano MJ, Gandara DR, Troncone G, Rolfo C
11/2021 - Expert review of molecular diagnostics
Autores: Aymard C, Kanso H, Serrano MJ, Pagán R, Noguer T, Istamboulie G
02/2022 - Food chemistry
Autores: Serrano MJ, Mata L, García-Gonzalo D, Antón A, Razquin P, Condón S, Pagán R
08/2021 - Foods (Basel, Switzerland)
Autores: Serrano MJ, García-Gonzalo D, Abilleira E, Elorduy J, Mitjana O, Falceto MV, Laborda A, Bonastre C, Mata L, Condón S, Pagán R
06/2021 - Antibiotics (Basel, Switzerland)
Autores: Dahinten-Bailey H, Serrano MJ, Alonso-Ascencio M, Cruz-Font JJ, Rosito-Prado I, Ruiz-Villanueva KJA, Vásquez-Almazan C, Ariano-Sánchez D
05/2021 - Zootaxa
Autores: Simon I, Perales S, Casado-Medina L, Rodríguez-Martínez A, Garrido-Navas MDC, Puche-Sanz I, Diaz-Mochon JJ, Alaminos C, Lupiañez P, Lorente JA, Serrano MJ, Real PJ
03/2021 - Cancers
Autores: Pisapia P, Costa JL, Pepe F, Russo G, Gragnano G, Russo A, Iaccarino A, de Miguel-Perez D, Serrano MJ, Denninghoff V, Quagliata L, Rolfo C, Malapelle U
05/2021 - Critical reviews in oncology/hematology
Autores: Ortega FG, Regiart MD, Rodríguez-Martínez A, de Miguel-Pérez D, Serrano MJ, Lorente JA, Tortella G, Rubilar O, Sapag K, Bertotti M, Fernández-Baldo MA
01/2021 - Analytical chemistry
Autores: Garrido-Navas MC, García-Díaz A, Molina-Vallejo MP, González-Martínez C, Alcaide Lucena M, Cañas-García I, Bayarri C, Delgado JR, González E, Lorente JA, Serrano MJ
11/2020 - Cancers
Autores: Serrano MJ, Lorente JA
11/2020 - Cancers
Autores: Serrano MJ, Garrido-Navas MC, Diaz Mochon JJ, Cristofanilli M, Gil-Bazo I, Pauwels P, Malapelle U, Russo A, Lorente JA, Ruiz-Rodriguez AJ, Paz-Ares LG, Vilar E, Raez LE, Cardona AF, Rolfo C, International Society of Liquid Biopsy
11/2020 - Cancer discovery
Autores: Connors D, Allen J, Alvarez JD, Boyle J, Cristofanilli M, Hiller C, Keating S, Kelloff G, Leiman L, McCormack R, Merino D, Morgan E, Pantel K, Rolfo C, Serrano MJ, Pia Sanzone A, Schlange T, Sigman C, Stewart M
12/2020 - Critical reviews in oncology/hematology
Autores: Rolfo C, Cardona AF, Cristofanilli M, Paz-Ares L, Diaz Mochon JJ, Duran I, Raez LE, Russo A, Lorente JA, Malapelle U, Gil-Bazo I, Jantus-Lewintre E, Pauwels P, Mok T, Serrano MJ, ISLB
10/2020 - Critical reviews in oncology/hematology
Autores: Rolfo C, Cardona AF, Cristofanilli M, Paz-Ares L, Diaz Mochon JJ, Duran I, Raez LE, Russo A, Lorente JA, Malapelle U, Gil-Bazo I, Jantus-Lewintre E, Pauwels P, Mok T, Serrano MJ, ISLB
07/2020 - Critical reviews in oncology/hematology
Autores: Serrano MJ, Exposito-Hernández J, Guerrero R, Lopez-Hidalgo J, Aguilar M, Lorente JA, de Álava E, Garrido-Navas MC
04/2020 - Translational lung cancer research
Autores: Serrano MJ, Mitjana O, Bonastre C, Laborda A, Falceto MV, García-Gonzalo D, Abilleira E, Elorduy J, Bousquet-Melou A, Mata L, Condón S, Pagán R
04/2020 - Antibiotics (Basel, Switzerland)
Autores: de Miguel Pérez D, Rodriguez Martínez A, Ortigosa Palomo A, Delgado Ureña M, Garcia Puche JL, Robles Remacho A, Exposito Hernandez J, Lorente Acosta JA, Ortega Sánchez FG, Serrano MJ
03/2020 - Scientific reports
Autores: de Miguel-Pérez D, Bayarri-Lara CI, Ortega FG, Russo A, Moyano Rodriguez MJ, Alvarez-Cubero MJ, Maza Serrano E, Lorente JA, Rolfo C, Serrano MJ
11/2019 - Cancers
Autores: Garrido-Navas C, de Miguel-Perez D, Exposito-Hernandez J, Bayarri C, Amezcua V, Ortigosa A, Valdivia J, Guerrero R, Garcia Puche JL, Lorente JA, Serrano MJ
11/2019 - Cells
Autores: González-Herrera L, Márquez-Ruiz AB, Serrano MJ, Ramos V, Lorente JA, Valenzuela A
09/2019 - Forensic science international
Autores: Romero-Palacios PJ, Alcázar-Navarrete B, Díaz Mochón JJ, de Miguel-Pérez D, López Hidalgo JL, Garrido-Navas MDC, Quero Valenzuela F, Lorente JA, Serrano MJ
04/2019 - Critical reviews in oncology/hematology
Autores: Malapelle U, Raez LE, Serrano MJ, Rolfo C, International Society of Liquid Biopsies (ISLB)
12/2018 - Journal of thoracic disease
Autores: Rodríguez-Martínez A, de Miguel-Pérez D, Ortega FG, García-Puche JL, Robles-Fernández I, Exposito J, Martorell-Marugan J, Carmona-Sáez P, Garrido-Navas MDC, Rolfo C, Ilyine H, Lorente JA, Legueren M, Serrano MJ
02/2019 - Breast cancer research : BCR
Autores: Ortega FG, Piguillem SV, Messina GA, Tortella GR, Rubilar O, Jiménez Castillo MI, Lorente JA, Serrano MJ, Raba J, Fernández Baldo MA
03/2019 - Talanta
Autores: Delgado-Ureña M, Ortega FG, de Miguel-Pérez D, Rodriguez-Martínez A, García-Puche JL, Ilyine H, Lorente JA, Exposito-Hernandez J, Garrido-Navas MC, Delgado-Ramirez M, Serrano MJ
09/2018 - Journal of translational medicine
Autores: Cozar JM, Robles-Fernandez I, Martinez-Gonzalez LJ, Pascual-Geler M, Rodriguez-Martinez A, Serrano MJ, Lorente JA, Alvarez-Cubero MJ
01/2018 - Mutation research. Reviews in mutation research
Autores: Herranz M, Pole I, Ozere I, Chiner-Oms Á, Martínez-Lirola M, Pérez-García F, Gijón P, Serrano MJR, Romero LC, Cuevas O, Comas I, Bouza E, Pérez-Lago L, García-de-Viedma D
01/2018 - Frontiers in microbiology
Autores: Reclusa P, Taverna S, Pucci M, Durendez E, Calabuig S, Manca P, Serrano MJ, Sober L, Pauwels P, Russo A, Rolfo C
10/2017 - Journal of thoracic disease
Autores: Puche-Sanz I, Alvarez-Cubero MJ, Pascual-Geler M, Rodríguez-Martínez A, Delgado-Rodríguez M, García-Puche JL, Expósito J, Robles-Fernández I, Entrala-Bernal C, Lorente JA, Cózar-Olmo JM, Serrano MJ
07/2017 - Oncotarget
Autores: Robles-Fernandez I, Martinez-Gonzalez LJ, Pascual-Geler M, Cozar JM, Puche-Sanz I, Serrano MJ, Lorente JA, Alvarez-Cubero MJ
10/2017 - PloS one
Autores: Alvarez Cubero MJ, Lorente JA, Robles-Fernandez I, Rodriguez-Martinez A, Puche JL, Serrano MJ
01/2017 - Methods in molecular biology (Clifton, N.J.)
Autores: Ibrahim I, Serrano MJ, Ruest LB, Svoboda KKH
11/2017 - Journal of dental research
Autores: Serrano MJ, Alvarez-Cubero MJ, De Miguel Pérez D, Rodríguez-Martínez A, Gonzalez-Herrera L, Robles-Fernandez I, Hernandez JE, Puche JLG, Lorente JA
01/2017 - Advances in experimental medicine and biology
Autores: Bayarri-Lara CI, de Miguel Pérez D, Cueto Ladrón de Guevara A, Rodriguez Fernández A, Puche JL, Sánchez-Palencia Ramos A, Ruiz Zafra J, Giraldo Ospina CF, Delgado-Rodríguez M, Expósito Ruiz M, Moyano Rodriguez MJ, Lorente JA, Serrano MJ
07/2017 - European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Autores: Marcén M, Ruiz V, Serrano MJ, Condón S, Mañas P
01/2017 - International journal of food microbiology
Autores: Gayán E, Serrano MJ, Álvarez I, Condón S
12/2016 - Food microbiology
Autores: Piñeiro Z, Marrufo-Curtido A, Serrano MJ, Palma M
06/2016 - Molecules (Basel, Switzerland)
Autores: Bayarri-Lara C, Ortega FG, Cueto Ladrón de Guevara A, Puche JL, Ruiz Zafra J, de Miguel-Pérez D, Ramos AS, Giraldo-Ospina CF, Navajas Gómez JA, Delgado-Rodriguez M, Lorente JA, Serrano MJ
02/2016 - PloS one
Autores: Melero JT, Ortega FG, Gonzalez AM, Carmona-Saez P, Garcia Puche JL, Sugarbaker PH, Delgado M, Lorente JA, Serrano MJ
03/2016 - Surgery
Autores: Ibrahim I, Serrano MJ, Svoboda KK
09/2015 - Journal of visualized experiments : JoVE
Autores: Serrano MJ, Liu J, Svoboda KK, Nawshad A, Benson MD
12/2015 - Journal of cellular physiology
Autores: Ortega FG, Fernández-Baldo MA, Fernández JG, Serrano MJ, Sanz MI, Diaz-Mochón JJ, Lorente JA, Raba J
03/2015 - International journal of nanomedicine
Autores: Ortega FG, Lorente JA, Garcia Puche JL, Ruiz MP, Sanchez-Martin RM, de Miguel-Pérez D, Diaz-Mochon JJ, Serrano MJ
03/2015 - Scientific reports
Autores: Alvarez-Cubero MJ, Vázquez-Alonso F, Puche-Sanz I, Ortega FG, Martin-Prieto M, Garcia-Puche JL, Pascual-Geler M, Lorente JA, Cozar-Olmo JM, Serrano MJ
01/2016 - Current drug targets
Autores: Gayán E, Serrano MJ, Pagán R, Álvarez I, Condón S
04/2015 - Food microbiology
Autores: Nadal R, Salido M, Nonell L, Rodríguez-Rivera M, Puigdecanet E, Garcia-Puche JL, Macià M, Corominas JM, Serrano MJ, Lorente JA, Solé F
02/2015 - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Autores: Serrano MJ, Ortega FG, Alvarez-Cubero MJ, Nadal R, Sanchez-Rovira P, Salido M, Rodríguez M, García-Puche JL, Delgado-Rodriguez M, Solé F, García MA, Perán M, Rosell R, Marchal JA, Lorente JA
09/2014 - Oncotarget
Autores: Serrano MJ, Vives M, Mateu C, Vicens C, Molina R, Puebla-Guedea M, Gili M
05/2014 - Actas espanolas de psiquiatria
Autores: Serrano MJ, So S, Hinton RJ
07/2014 - Archives of oral biology
Autores: Ibarra O, Gili M, Roca M, Vives M, Serrano MJ, Pareja A, García-Campayo J, Gómez-Juanes R, García-Toro M
10/2014 - Nutricion hospitalaria
Autores: Nadal R, Ortega FG, Salido M, Lorente JA, Rodríguez-Rivera M, Delgado-Rodríguez M, Macià M, Fernández A, Corominas JM, García-Puche JL, Sánchez-Rovira P, Solé F, Serrano MJ
11/2013 - International journal of cancer
Autores: Nadal R, Lorente JA, Rosell R, Serrano MJ
04/2013 - Expert review of molecular diagnostics
Autores: Mayo C, Ortega FG, Giménez-Capitán A, Molina-Vila MA, Serrano MJ, Viteri S, Costa C, Gascó A, Bertran-Alamillo J, Karachaliou N, Lorente JA, Tarón M, Rosell R
04/2013 - Translational lung cancer research
Autores: Serrano MJ, Rovira PS, Martínez-Zubiaurre I, Rodriguez MD, Fernández M, Lorente JA
07/2012 - Experimental and therapeutic medicine
Autores: Benson MD, Serrano MJ
09/2012 - Frontiers in physiology
Autores: Rosell R, Molina MA, Serrano MJ
10/2012 - The Lancet. Oncology
Autores: García-Toro M, Ibarra O, Gili M, Serrano MJ, Vives M, Monzón S, Bauzá N, Oliván B, Vicens E, Roca M
10/2012 - Revista de psiquiatria y salud mental
Autores: Gayán E, Serrano MJ, Raso J, Alvarez I, Condón S
12/2012 - Applied and environmental microbiology
Autores: Sachar A, Strom TA, San Miguel S, Serrano MJ, Svoboda KK, Liu X
11/2014 - Journal of tissue engineering and regenerative medicine
Autores: Sachar A, Strom TA, Serrano MJ, Benson MD, Opperman LA, Svoboda KK, Liu X
11/2012 - Journal of biomedical materials research. Part A
Autores: Nadal R, Fernandez A, Sanchez-Rovira P, Salido M, Rodríguez M, García-Puche JL, Macià M, Corominas JM, Delgado-Rodriguez M, Gonzalez L, Albanell J, Fernández M, Solé F, Lorente JA, Serrano MJ
05/2012 - Breast cancer research : BCR
Autores: García-Toro M, Ibarra O, Gili M, Serrano MJ, Oliván B, Vicens E, Roca M
10/2012 - Journal of affective disorders
Autores: Gili M, Luciano JV, Serrano MJ, Jiménez R, Bauza N, Roca M
10/2011 - The Journal of nervous and mental disease
Autores: Gili M, Luciano JV, Bauzá N, Aguado J, Serrano MJ, Armengol S, Roca M
09/2011 - BMC medical research methodology
Autores: Serrano MJ, Nadal R, Lorente JA, Salido M, Rodríguez R, Rodríguez M, Macià M, Sánchez-Rovira P, Corominas JM, González L, Vera L, Albanell J, Solé F
09/2011 - Annals of oncology : official journal of the European Society for Medical Oncology
Autores: Serrano MJ, Lorente JA, Delgado Rodríguez M, Fernández A, Fernández M, de la Torre C, Fernández Izquierdo J, Sánchez Rovira P
03/2011 - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Autores: Gili M, Sesé A, Bauza N, Serrano MJ, Salvador-Carulla L, Molina R, Roca M
01/2011 - International review of psychiatry (Abingdon, England)
Autores: San Miguel S, Serrano MJ, Sachar A, Henkemeyer M, Svoboda KK, Benson MD
02/2011 - Developmental dynamics : an official publication of the American Association of Anatomists
Autores: Roca M, Armengol S, García-García M, Rodriguez-Bayón A, Ballesta I, Serrano MJ, Comas A, Gili M
01/2011 - Comprehensive psychiatry
Autores: Serrano MJ, So S, Svoboda KK, Hinton RJ
06/2011 - Archives of oral biology
Autores: Garcia-Toro M, Ibarra O, Gili M, Salva J, Monzón S, Vives M, Serrano MJ, Garcia-Campayo J, Roca M
07/2010 - BMC public health
Autores: Monzón S, Gili M, Vives M, Serrano MJ, Bauza N, Molina R, García-Toro M, Salvà J, Llobera J, Roca M
06/2010 - BMC psychiatry
Autores: Zambrana AR, Martín FL, Blanco JZ, Blanco JM, Serrano MJ, Suárez JL
06/2009 - Actas urologicas espanolas
Autores: Serrano MJ, Sánchez-Rovira P, Delgado-Rodriguez M, Gaforio JJ
04/2009 - Cancer biology & therapy
Autores: Martín A, Herránz M, Serrano MJ, Bouza E, García de Viedma D
07/2007 - BMC microbiology
Autores: Roca M, Martin-Santos R, Saiz J, Obiols J, Serrano MJ, Torrens M, Subirà S, Gili M, Navinés R, Ibañez A, Nadal M, Barrantes N, Cañellas F
01/2007 - European psychiatry : the journal of the Association of European Psychiatrists
Autores: Muñoz P, Rodríguez M, Giannella M, Vega A, Anaya F, Serrano MJ, Bouza E
03/2007 - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Autores: Tomàs C, Cañellas F, Rodríguez V, Picornell A, Lafau O, Nadal M, Roca M, Serrano MJ, Castro JA, Ramon MM
08/2006 - Psychiatric genetics
Autores: Garcia de Viedma D, Lorenzo G, Cardona PJ, Rodriguez NA, Gordillo S, Serrano MJ, Bouza E
12/2005 - The Journal of infectious diseases
Autores: Massiot G, Long C, David B, Serrano MJ, Daubié F, Alby F, Ausseil F, Knibiehler M, Moretti C, Hoffmann JS, Cazaux C, Lavaud C
07/2005 - Journal of natural products
Autores: Gaforio JJ, Serrano MJ, Sanchez-Rovira P, Sirvent A, Delgado-Rodriguez M, Campos M, de la Torre N, Algarra I, Dueñas R, Lozano A
12/2003 - International journal of cancer
Autores: Gaforio JJ, Ortega E, Algarra I, Serrano MJ, Alvarez de Cienfuegos G
11/2002 - Clinical and diagnostic laboratory immunology
Autores: Gaforio JJ, Serrano MJ, Algarra I, Ortega E, Alvarez de Cienfuegos G
09/2002 - Cytometry
Autores: Gaforio JJ, Serrano MJ, Ortega E, Algarra I, Alvarez de Cienfuegos G
06/2002 - Cytometry
Autores: Algarra I, Ortega E, Serrano MJ, Alvarez de Cienfuegos G, Gaforio JJ
07/2002 - FEMS immunology and medical microbiology
Autores: Serrano MJ, Sánchez-Rovira P, Algarra I, Jaén A, Lozano A, Gaforio JJ
05/2002 - Japanese journal of cancer research : Gann
Autores: Ortega E, Algarra I, Serrano MJ, Alvarez de Cienfuegos G, Gaforio JJ
07/2001 - Journal of immunological methods
Autores: Ortega E, Algarra I, Serrano MJ, de Pablo MA, Alvarez de Cienfuegos G, Gaforio JJ
08/2000 - FEMS immunology and medical microbiology
Autores: Algarra I, Perez M, Serrano MJ, Garrido F, Gaforio JJ
01/1998 - Invasion & metastasis
Autores: Diaz-Jimenez JP, Ballarin JI, Muñoz EF, Kovitz KL, Serrano MJ, Shirakura K
01/1995 - Diagnostic and therapeutic endoscopy
Autores: Soria C, Freire P, Serrano MJ, Guerrero A
01/1990 - Enfermedades infecciosas y microbiologia clinica
Autores: Guerrero A, Serrano MJ
03/1989 - Medicina clinica
Autores: Guerrero A, Serrano MJ, García Moncó C
03/1988 - Medicina clinica
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