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Nucleic acids are very flexible molecules that can adopt different conformational structures. While in living systems DNA is mostly organized in the form of a double helix and RNA is single-stranded, guanine-rich sequences exist in alternative structural forms known as G-quadruplex nucleic acids (G4). G4 are made up of four guanine bases arranged in an intracatenary square planar conformation (G tetrad) linked by Hoogsteen hydrogen bonds and further stabilized by an alkaline cation such as K+.
Inicio - Área Aplicada: Medicina Personalizada - Terapias Avanzadas - Gene Regulation, Stem Cells & Development | PI’s: Dr. Pedro Real y Dr. Verónica Ramos
Our research leverages stem cell models to study cancer development. Normal Stem Cells and Cancer Stem Cells share biological and molecular characteristics, such as similar key signaling pathways, marker expression profiles and the ability for selfrenewal. Also, cellular reprogramming and oncogenic transformation are processes that share many similarities and are controlled by the same pluripotency genes. We are generating a human pluripotent stem cell (hPSCs)-based platform to discover new biomarkers and therapeutic targets for cancer, which also will allow us to study the mechanisms of oncogenic transformation.
BSS, an extremely rare disorder, is distinguished by a diminished count of enlarged and functionally impaired platelets. Afflicted individuals endure uncontrolled bleeding, often escalating into life-threatening scenarios. In collaboration with Dr. Martin’s research group (GENyO), along with various national and international partners, we have successfully demonstrated the effectiveness of lentiviral vectors in genetically rescuing the GP9 gene within cellular models and primary cells derived from BSS Type C patients (Martinez-Navajas G et al. 2023).
Currently, we are analyzing the phenotype of an BSS Type C animal model (Gp9-KO) generated in our laboratory. Preliminary results suggest that Gp9-KO mice manifest similar symptoms to those observed in human patients, such as macrothrombocytopenia. Concurrently, we are performing ex vivo genetic rescue of hematopoietic stem cells extracted from these mice using the same lentiviral vectors that have been shown to be effective in vitro. These results are pivotal to complete the preclinical phase of our innovative treatment, allowing for a comprehensive assessment of both functionality and biosafety in this novel genecell therapy designed for BSS Type C patients.
To date, clinical interventions for BSS patients have primarily centered on providing temporary relief from symptoms, mitigating macrothrombocytopenia, and enhancing platelet clotting. Our proposal represents the first curative therapy described to treat BSS Type C patients. Our studies open the possibility of extending this kind of therapeutic approach not only to the other two BSS subtypes (Type A 86 STRATEGIC PLAN 2024-2027 and Type B), but also to a spectrum of platelet diseases of genetic origin, known as genetic thrombopathies.
The detection of early PDAC markers in plasma holds the potential to significantly enhance therapeutic interventions for patients in the early stages of the disease. Moreover, it opens avenues for the development of novel therapies designed to impede the communication pathways between platelets and pancreatic tumor cells. This communication plays a pivotal role in the initiation of metastasis, a process accountable for the majority of PDAC-related fatalities.
Pancreatic cancer (PDAC) is one of the most aggressive solid tumors, with a 5-year survival rate of less than 8%. This low life expectancy is associated to delayed diagnosis often with metastases in distant organs. Notably, PDAC is characterized by a strong association with a state of hypercoagulability, driven by an increase in the both number and activity of platelets; a phenomenon orchestrated through communication between tumor cells and platelets. In collaboration with clinical researchers from ibs-Granada, we proposed the use of platelets and the extracellular vesicles (EVs) generated by them as rich sources of information for PDAC.
Platelets have significant advantages compared to other blood components: they are abundant, have a reduced half-life and interact with tumor cells. This interaction involves the reciprocal exchange of EVs loaded with biomolecules (proteins and nucleic acids) that exert an impact on the cells that incorporate them.
Our aim is to identify distinctive platelet or EVs biomarkers exclusive to the early stages of PDAC for utilization in an early diagnostic kit. In pursuit of this objective, we employ in vitro cellular models that faithfully replicate the genetic progression of the disease, experimental animal models, and plasma samples from individuals diagnosed with PDAC.
We are mainly focusing in Pediatric Myeloid Leukemia, a rare a heterogeneous group of diseases. About 50% of patients experience a relapse, and the overall survival ranges between 20 to 70%, depending on the leukemia subtype. There is limited progress on targeted therapies, mainly due to its low frequency, the wide variety of genetic alterations associated to it and the scarce material available for studies. We are generating stem cells models for drug screening and understanding of fundamental pathogenic mechanisms.
Our ultimate goal is to gain knowledge on the cellular and molecular similarities and differences between a normal stem cell and its malignant counterpart, to understand, identify and attack cancer stem cells.
Entidad concedente: Ministerio Ciencia, Innovación y Universidades.
Entidad concedente: Ministerio Ciencia, Innovación y Universidades.
Entidad concedente: Ministerio Ciencia, Innovación y Universidades.
Programa Operativo FEDER Andalucía 2014-2020.
Ref.: E-CTS-12-UGR20.
IP: Rosa Mª Montes Lorenzo.
Programa Operativo FEDER Andalucía 2021-2027.
Ref.: C-EXP-247-UGR23.
IP: Rosa Mª Montes Lorenzo.
Autores: Ellson I, Martorell-Marugán J, Carmona-Sáez P, Ramos-Mejia V
08/2024 - NPJ genomic medicine
Autores: López-Ornelas A, Escobedo-Avila I, Ramírez-García G, Lara-Rodarte R, Meléndez-Ramírez C, Urrieta-Chávez B, Barrios-García T, Cáceres-Chávez VA, Flores-Ponce X, Carmona F, Reynoso CA, Aguilar C, Kerik NE, Rocha L, Verdugo-Díaz L, Treviño V, Bargas J, Ramos-Mejía V, Fernández-Ruiz J, Campos-Romo A, Velasco I
11/2023 - Cells
Autores: Martinez-Navajas G, Ceron-Hernandez J, Simon I, Lupiañez P, Diaz-McLynn S, Perales S, Modlich U, Guerrero JA, Martin F, Sevivas T, Lozano ML, Rivera J, Ramos-Mejia V, Tersteeg C, Real PJ
06/2023 - Molecular therapy. Nucleic acids
Autores: Domingo-Reinés J, Montes R, Garcia-Moreno A, Gallardo A, Sanchez-Manas JM, Ellson I, Lamolda M, Calabro C, López-Escamez JA, Catalina P, Carmona-Sáez P, Real PJ, Landeira D, Ramos-Mejia V
06/2023 - Cell death & disease
Autores: Estupiñán Ó, Rey V, Tornín J, Murillo D, Gallego B, Huergo C, Blanco-Lorenzo V, Victoria González M, Rodríguez A, Moris F, González J, Ayllón V, Ramos-Mejía V, Bigas A, Rodríguez R
06/2023 - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Autores: Domingo-Reinés J, Martínez-Navajas G, Montes R, Lamolda M, Simón I, Castaño J, Ríos-Pelegrina R, Lopez-Hidalgo JL, García Del Moral R, Marchal JA, Real PJ, Ramos-Mejía V
06/2022 - Frontiers in cell and developmental biology
Autores: Sanabria-de la Torre R, Martínez-Heredia L, González-Salvatierra S, Andújar-Vera F, Iglesias-Baena I, Villa-Suárez JM, Contreras-Bolívar V, Corbacho-Soto M, Martínez-Navajas G, Real PJ, García-Fontana C, Muñoz-Torres M, García-Fontana B
04/2022 - Frontiers in endocrinology
Autores: Ramos-Mejia V, Arellano-Galindo J, Mejía-Arangure JM, Cruz-Munoz ME
04/2022 - Frontiers in immunology
Autores: Rodriguez-Martinez A, Simon-Saez I, Perales S, Garrido-Navas C, Russo A, de Miguel-Perez D, Puche-Sanz I, Alaminos C, Ceron J, Lorente JA, Molina MP, Gonzalez C, Cristofanilli M, Ortigosa-Palomo A, Real PJ, Rolfo C, Serrano MJ
02/2022 - Theranostics
Autores: Yan Q, Wulfridge P, Doherty J, Fernandez-Luna JL, Real PJ, Tang HY, Sarma K
01/2022 - Nature communications
Autores: Díaz de la Guardia R, Velasco-Hernandez T, Gutiérrez-Agüera F, Roca-Ho H, Molina O, Nombela-Arrieta C, Bataller A, Fuster JL, Anguita E, Vives S, Zamora L, Nomdedeu J, Gómez-Casares MT, Ramírez-Orellana M, Lapillonne H, Ramos-Mejia V, Rodríguez-Manzaneque JC, Bueno C, Lopez-Millan B, Menéndez P
12/2021 - Blood advances
Autores: Cortijo-Gutiérrez M, Sánchez-Hernández S, Tristán-Manzano M, Maldonado-Pérez N, Lopez-Onieva L, Real PJ, Herrera C, Marchal JA, Martin F, Benabdellah K
08/2021 - Pharmaceutics
Autores: Simon I, Perales S, Casado-Medina L, Rodríguez-Martínez A, Garrido-Navas MDC, Puche-Sanz I, Diaz-Mochon JJ, Alaminos C, Lupiañez P, Lorente JA, Serrano MJ, Real PJ
03/2021 - Cancers
Autores: Gallardo A, Molina A, Asenjo HG, Martorell-Marugán J, Montes R, Ramos-Mejia V, Sanchez-Pozo A, Carmona-Sáez P, Lopez-Onieva L, Landeira D
04/2020 - Life science alliance
Autores: Carrillo-Gálvez AB, Gálvez-Peisl S, González-Correa JE, de Haro-Carrillo M, Ayllón V, Carmona-Sáez P, Ramos-Mejía V, Galindo-Moreno P, Cara FE, Granados-Principal S, Muñoz P, Martin F, Anderson P
05/2020 - Stem cells translational medicine
Autores: Lamolda M, Montes R, Simón I, Perales S, Martínez-Navajas G, Lopez-Onieva L, Ríos-Pelegrina R, Del Moral RG, Griñan-Lison C, Marchal JA, Lozano ML, Ramos-Mejia V, Rivera J, Bastida JM, Real PJ
12/2019 - Stem cell research
Autores: García-Fontana C, Villa-Suárez JM, Andújar-Vera F, González-Salvatierra S, Martínez-Navajas G, Real PJ, Gómez Vida JM, de Haro T, García-Fontana B, Muñoz-Torres M
07/2019 - Scientific reports
Autores: Montes R, Mollinedo P, Perales S, Gonzalez-Lamuño D, Ramos-Mejía V, Fernandez-Luna JL, Real PJ
05/2019 - Stem cell research
Autores: Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambilet D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P
06/2019 - Haematologica
Autores: Sánchez-Hernández S, Gutierrez-Guerrero A, Martín-Guerra R, Cortijo-Gutierrez M, Tristán-Manzano M, Rodriguez-Perales S, Sanchez L, Garcia-Perez JL, Chato-Astrain J, Fernandez-Valades R, Carrillo-Galvez AB, Anderson P, Montes R, Real PJ, Martin F, Benabdellah K
12/2018 - Molecular therapy. Nucleic acids
Autores: Velasco I, Kunath T, Ramos-Mejía V, Velasco-Velázquez MA
01/2017 - Stem cells international
Autores: Domingo-Reines J, López-Ornelas A, Montes R, Romero T, Rodriguez-Llamas JL, Lara-Rodarte R, González-Pozas F, Ayllon V, Menendez P, Velasco I, Ramos-Mejia V
12/2017 - Stem cell research
Autores: González-Pozas F, Montes R, Domingo-Reinés J, Ayllón V, Ramos-Mejía V
12/2017 - Stem cell research
Autores: Navarro-Montero O, Ayllon V, Lamolda M, López-Onieva L, Montes R, Bueno C, Ng E, Guerrero-Carreno X, Romero T, Romero-Moya D, Stanley E, Elefanty A, Ramos-Mejia V, Menendez P, Real PJ
11/2017 - Stem cells (Dayton, Ohio)
Autores: Ayllón V, Vogel-González M, González-Pozas F, Domingo-Reinés J, Montes R, Morales-Cacho L, Ramos-Mejía V
03/2017 - Stem cell research
Autores: Lopez-Onieva L, Lamolda M, Montes R, Lozano ML, Vicente V, Rivera J, Ramos-Mejía V, Real PJ
04/2017 - Stem cell research
Autores: López-Ruiz E, Venkateswaran S, Perán M, Jiménez G, Pernagallo S, Díaz-Mochón JJ, Tura-Ceide O, Arrebola F, Melchor J, Soto J, Rus G, Real PJ, Diaz-Ricart M, Conde-González A, Bradley M, Marchal JA
03/2017 - Scientific reports
Autores: Lopez-Onieva L, Machuca C, Lamolda M, Montes R, Lozano ML, Vicente V, Rivera J, Ramos-Mejía V, Real PJ
11/2016 - Stem cell research
Autores: Lopez-Onieva L, Montes R, Lamolda M, Romero T, Ayllon V, Lozano ML, Vicente V, Rivera J, Ramos-Mejía V, Real PJ
09/2016 - Stem cell research
Autores: Muñoz-López A, Romero-Moya D, Prieto C, Ramos-Mejía V, Agraz-Doblas A, Varela I, Buschbeck M, Palau A, Carvajal-Vergara X, Giorgetti A, Ford A, Lako M, Granada I, Ruiz-Xivillé N, Rodríguez-Perales S, Torres-Ruíz R, Stam RW, Fuster JL, Fraga MF, Nakanishi M, Cazzaniga G, Bardini M, Cobo I, Bayon GF, Fernandez AF, Bueno C, Menendez P
10/2016 - Stem cell reports
Autores: González-Pozas F, Montes R, López-Onieva L, Romero T, Domingo-Reinés J, Real PJ, Ramos-Mejía V, Ayllón V
05/2016 - Stem cell research
Autores: Lopez-Onieva L, Montes R, Lamolda M, Romero T, Ayllon V, Lozano ML, Vicente V, Rivera J, Ramos-Mejía V, Real PJ
05/2016 - Stem cell research
Autores: Carballo-Molina OA, Sánchez-Navarro A, López-Ornelas A, Lara-Rodarte R, Salazar P, Campos-Romo A, Ramos-Mejía V, Velasco I
06/2016 - Tissue engineering. Part A
Autores: Montes R, Romero T, Cabrera S, Ayllon V, Lopez-Escamez JA, Ramos-Mejia V, Real PJ
11/2015 - Stem cell research
Autores: Toscano MG, Muñoz P, Sánchez-Gilabert A, Cobo M, Benabdellah K, Anderson P, Ramos-Mejía V, Real PJ, Neth O, Molinos-Quintana A, Gregory PD, Holmes MC, Martin F
02/2016 - Molecular therapy : the journal of the American Society of Gene Therapy
Autores: Cabrera S, Ji AR, Frejo L, Ramos-Mejia V, Romero T, Real P, Lopez-Escamez JA
09/2015 - Stem cell research
Autores: Ayllón V, Bueno C, Ramos-Mejía V, Navarro-Montero O, Prieto C, Real PJ, Romero T, García-León MJ, Toribio ML, Bigas A, Menendez P
08/2015 - Leukemia
Autores: Toscano MG, Navarro-Montero O, Ayllon V, Ramos-Mejia V, Guerrero-Carreno X, Bueno C, Romero T, Lamolda M, Cobo M, Martin F, Menendez P, Real PJ
01/2015 - Molecular therapy : the journal of the American Society of Gene Therapy
Autores: Ramos-Mejía V, Navarro-Montero O, Ayllón V, Bueno C, Romero T, Real PJ, Menendez P
11/2014 - Blood
Autores: Velasco I, Salazar P, Giorgetti A, Ramos-Mejía V, Castaño J, Romero-Moya D, Menendez P
11/2014 - Stem cells (Dayton, Ohio)
Autores: Montes R, Ayllón V, Prieto C, Bursen A, Prelle C, Romero-Moya D, Real PJ, Navarro-Montero O, Chillón C, Marschalek R, Bueno C, Menendez P
03/2014 - Leukemia
Autores: Real PJ, Navarro-Montero O, Ramos-Mejía V, Ayllón V, Bueno C, Menéndez P
06/2013 - Blood
Autores: Bueno C, Ayllón V, Montes R, Navarro-Montero O, Ramos-Mejia V, Real PJ, Romero-Moya D, Araúzo-Bravo MJ, Menendez P
05/2013 - Blood
Autores: McIntyre BA, Ramos-Mejia V, Rampalli S, Mechael R, Lee JH, Alev C, Sheng G, Bhatia M
02/2013 - Blood
Autores: Navarro-Montero O, Romero-Moya D, Montes R, Ramos-Mejía V, Bueno C, Real PJ, Menendez P
11/2012 - Clinical immunology (Orlando, Fla.)
Autores: Muñoz P, Toscano MG, Real PJ, Benabdellah K, Cobo M, Bueno C, Ramos-Mejía V, Menendez P, Anderson P, Martín F
01/2012 - PloS one
Autores: Ramos-Mejía V, Montes R, Bueno C, Ayllón V, Real PJ, Rodríguez R, Menendez P
01/2012 - PloS one
Autores: Ramos-Mejia V, Fraga MF, Menendez P
05/2012 - Trends in molecular medicine
Autores: Real PJ, Ligero G, Ayllon V, Ramos-Mejia V, Bueno C, Gutierrez-Aranda I, Navarro-Montero O, Lako M, Menendez P
07/2012 - Molecular therapy : the journal of the American Society of Gene Therapy
Autores: Bueno C, Montes R, Melen GJ, Ramos-Mejia V, Real PJ, Ayllón V, Sanchez L, Ligero G, Gutierrez-Aranda I, Fernández AF, Fraga MF, Moreno-Gimeno I, Burks D, Plaza-Calonge Mdel C, Rodríguez-Manzaneque JC, Menendez P
06/2012 - Cell research
Autores: Sánchez L, Gutierrez-Aranda I, Ligero G, Martín M, Ayllón V, Real PJ, Ramos-Mejía V, Bueno C, Menendez P
05/2012 - Tissue engineering. Part C, Methods
Autores: Yung S, Ledran M, Moreno-Gimeno I, Conesa A, Montaner D, Dopazo J, Dimmick I, Slater NJ, Marenah L, Real PJ, Paraskevopoulou I, Bisbal V, Burks D, Santibanez-Koref M, Moreno R, Mountford J, Menendez P, Armstrong L, Lako M
12/2011 - Human molecular genetics
Autores: Ramos-Mejía V, Fernández AF, Ayllón V, Real PJ, Bueno C, Anderson P, Martín F, Fraga MF, Menendez P
06/2012 - Stem cells and development
Autores: Calvanese V, Fernández AF, Urdinguio RG, Suárez-Alvarez B, Mangas C, Pérez-García V, Bueno C, Montes R, Ramos-Mejía V, Martínez-Camblor P, Ferrero C, Assenov Y, Bock C, Menendez P, Carrera AC, Lopez-Larrea C, Fraga MF
01/2012 - Nucleic acids research
Autores: Sánchez L, Gutierrez-Aranda I, Ligero G, Rubio R, Muñoz-López M, García-Pérez JL, Ramos V, Real PJ, Bueno C, Rodríguez R, Delgado M, Menendez P
02/2011 - Stem cells (Dayton, Ohio)
Autores: Ramos-Mejia V, Bueno C, Roldan M, Sanchez L, Ligero G, Menendez P, Martin M
05/2012 - Stem cells and development
Autores: De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cavé H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA
11/2010 - Nature medicine
Autores: Ramos-Mejia V, Muñoz-Lopez M, Garcia-Perez JL, Menendez P
10/2010 - Cell research
Autores: Ramos-Mejia V, Melen GJ, Sanchez L, Gutierrez-Aranda I, Ligero G, Cortes JL, Real PJ, Bueno C, Menendez P
12/2010 - Molecular therapy : the journal of the American Society of Gene Therapy
Autores: Gutierrez-Aranda I, Ramos-Mejia V, Bueno C, Munoz-Lopez M, Real PJ, Mácia A, Sanchez L, Ligero G, Garcia-Parez JL, Menendez P
09/2010 - Stem cells (Dayton, Ohio)
Autores: Hong SH, Werbowetski-Ogilvie T, Ramos-Mejia V, Lee JB, Bhatia M
09/2010 - Stem cell research
Autores: Cortes JL, Sanchez L, Ligero G, Gutierrez-Aranda I, Catalina P, Elosua C, Leone PE, Montes R, Bueno C, Ramos-Mejía V, Maleno I, García-Pérez JL, Menendez P
08/2009 - Human reproduction (Oxford, England)
Autores: Real PJ, Ferrando AA
08/2009 - Leukemia
Autores: Vijayaragavan K, Szabo E, Bossé M, Ramos-Mejia V, Moon RT, Bhatia M
03/2009 - Cell stem cell
Autores: Werbowetski-Ogilvie TE, Bossé M, Stewart M, Schnerch A, Ramos-Mejia V, Rouleau A, Wynder T, Smith MJ, Dingwall S, Carter T, Williams C, Harris C, Dolling J, Wynder C, Boreham D, Bhatia M
01/2009 - Nature biotechnology
Autores: Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, Sulis ML, Barnes K, Sawai C, Homminga I, Meijerink J, Aifantis I, Basso G, Cordon-Cardo C, Ai W, Ferrando A
01/2009 - Nature medicine
Autores: Sulis ML, Williams O, Palomero T, Tosello V, Pallikuppam S, Real PJ, Barnes K, Zuurbier L, Meijerink JP, Ferrando AA
08/2008 - Blood
Autores: Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA
10/2007 - Nature medicine
Autores: Bendall SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, Ramos-Mejia V, Rouleau A, Yang J, Bossé M, Lajoie G, Bhatia M
08/2007 - Nature
Autores: Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA
11/2006 - Proceedings of the National Academy of Sciences of the United States of America
Autores: Blázquez C, Carracedo A, Barrado L, Real PJ, Fernández-Luna JL, Velasco G, Malumbres M, Guzmán M
12/2006 - FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Autores: Benito A, Gutierrez O, Pipaon C, Real PJ, Gachon F, Ritchie AE, Fernandez-Luna JL
12/2006 - The Journal of biological chemistry
Autores: Real PJ, Sanz C, Gutierrez O, Pipaon C, Zubiaga AM, Fernandez-Luna JL
10/2006 - FEBS letters
Autores: Palomero T, Barnes KC, Real PJ, Glade Bender JL, Sulis ML, Murty VV, Colovai AI, Balbin M, Ferrando AA
07/2006 - Leukemia
Autores: Fontalba A, Real PJ, Fernandez-Luna JL, Agirre X, Prosper F, Richard C
10/2006 - Leukemia research
Autores: Real PJ, Benito A, Cuevas J, Berciano MT, de Juan A, Coffer P, Gomez-Roman J, Lafarga M, Lopez-Vega JM, Fernandez-Luna JL
09/2005 - Cancer research
Autores: Pipaon C, Real PJ, Fernandez-Luna JL
08/2005 - FEBS letters
Autores: Ramos-Mejía V, Escalante-Alcalde D, Kunath T, Ramírez L, Gertsenstein M, Nagy A, Lomelí H
01/2005 - Developmental dynamics : an official publication of the American Association of Anatomists
Autores: Real PJ, Cao Y, Wang R, Nikolovska-Coleska Z, Sanz-Ortiz J, Wang S, Fernandez-Luna JL
11/2004 - Cancer research
Autores: Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL
10/2002 - Oncogene
Autores: Lomelí H, Ramos-Mejía V, Gertsenstein M, Lobe CG, Nagy A
02/2000 - Genesis (New York, N.Y. : 2000)
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