Transcriptomics of Tomorrow: Single Cell, Spatial and Artificial Intelligence

Yasuhiro Kojima is head of the Computational Life Sciences Laboratory at the National Cancer Centre Research Institute in Tokyo, a post he has held since 2023. He was educated entirely at the University of Tokyo, where he completed his PhD in computational biology, focusing on population genetics and gene regulatory networks, and subsequently undertook his postdoctoral research and taught at Nagoya University, during which time his work focused on deep generative models applied to single-cell and spatial transcriptomic data.

His research focuses on developing probabilistic and deep learning methods to infer cell-cell interactions from spatial data, reconstruct the dynamics of cellular states and link cellular heterogeneity to its microenvironment, with cancer as the main field of application. He has published in journals such as *Cell Systems*, *Genome Biology*, *Bioinformatics* and *Cell Reports*; he regularly collaborates with clinical and experimental groups on studies of colorectal, renal and brain cancers; and in recent years he has expanded his work to include the prediction of spatial gene expression from histopathological images.

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