NANOCHEMBIO: Development of therapeutic and diagnosis strategies

Home Research groups NANOCHEMBIO: Development of therapeutic and diagnosis strategies

NANOCHEMBIO: Development of therapeutic and diagnosis strategies

Dra. Rosario María Sánchez Martín

Information

Scientific interest areas

Chemical Biology, nanotechnology, nanotoxicology, nanosafety, characterisation of nanomaterials, biomedicine, molecular diagnosis, personalized medicine, biomaterials.

Research areas

  • Selective antitumoral therapy based on the use of nanodevices.
  • Chemical-based platforms for nucleic acid detection in liquid biopsy.
  • Integration of nanotechnology with dynamic chemistry for in situ miRNA analysis.
  • Peptide nucleic acids based approaches for gene editing.
  • Development of chemical platforms for isolation
  • labelling and analysis of exosomes.
  • Optimizacion of chemical strategies for selective drug release.
  • Nanotoxicology / Nanosafety.
  • Preclinical evaluation of nanodevices.
  • Development of biomaterials for cellular and protein control.

Technology platforms

    • Nanotechnology Platforms for selective delivery of therapeutic agents
    • HTS Platforms for biological systems
    • PCR-free Diagnostic Platforms for nucleic acid testing
    • Solid phase synthesis Platform- preparation of peptide, nucleic acid mimics and peptidomimetics
    • Biomaterial Platform for developing SMART materials
    • Preclinical evaluation Unit of nanomaterials

Funding

    • Agencia Ejecutiva de Investigación (REA) de la Comunidad Europea
    • Ministerio de Economía y Competitividad
    • Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía

Research group patents

Application Number: P201431357
Priority Date: 18/09/2014
Title: Procedure to detect circulating tumor cells, both circulating tumors cells of epithelial phenotype and circulating tumour cells having Epithelial-mesenchymal transition markers (EMTs), by using miRNA-21 as a biomarker.
Authors: Serrano,M.J., Diaz-Mochón, J.J, Ortega, F.G., Lorente, J.A. Garcia-Puche, J.L., Ruiz-Blas, M.P., Sánchez-Martín, R.M.

Application Number: WO2015140386-A1; ES2548927-A1
Priority Date: 21/03/2014
Title: New purine derivative, useful for preparing pharmaceutical composition or medicament for treating disease or condition mediated by death-associated protein kinase 1 (DAPK1), preferably cancer and leukemia
Authors: Molina Pineda de las Infantas, I., Torres Rusillo, S., Fernandez, P., Pineda de las Infantas y Villatoro, M.J., Diaz-Mochón, J.J, Unciti-Broceta, A.

Nº Solicitud: GB 0718255.3
Priority Date: 17/09/2007
Title: Nucleobase Characterisation
Authors: Bradley, M and Díaz-Mochón, J.J.

Application Number: PCT/GB2008/003185
Priority Date: 17/09/2007
Title: Nucleobase Characterisation
Authors: Bradley, M and Díaz-Mochón, J.J.

Application Number: GB 0904834.9.
Priority Date: 20/03/2009
Title: Polymer for growing cells
Authors: Hay, D., Pernagallo, S., Díaz-Mochón, J.J., Bradley, M., Iredale, J.

Publications

Selected publications

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Other groups
Area of Genomic Oncology
Area of Genomic Medicine